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Andrea Frilling image


Andrea Frilling



Special Interests

Endocrine surgery, thyroid surgery, parathyroids, adrenal, pancreas, Neuroendocrine tumors, Liverl metastasis




Professor Andrea Frilling is currently affiliated as Professor of Surgery and Chair in Endocrine Surgery with the Imperial College London, UK. She has authored - 400 peer reviewed scientific and clinical papers and contributed to - 20 books on diverse subjects on endocrine and hepato-pancreato-biliary surgery. She has received her primary medical education at the Ruhr University Bochum, Germany and the University Essen, Germany where she graduated in 1980. She has achieved a PhD degree summa cum laude at the Ruhr University Bochum for her work on X-linked dominant inheritance of phosphorylase kinase deficiency in mouse. Her residency was served at the University Duesseldorf, Germany where she remained on the surgical faculty as an Assistant Professor of Surgery. Her thesis on presymptomatic screening for medullary thyroid carcinoma in families of patients with multiple endocrine neoplasia syndrome type 2 was awarded with the von Langenbeck Price, the most prestigious Award of the German Surgical Society.

She took over a position of a Head of the Section for Endocrine Surgery at the University Hamburg, Germany and was offered a position of a Vice Chairman and Professor of Surgery at the Department of General, Visceral and Transplantation Surgery at the University Hospital Essen. She is member of several medical societies and has been a Visiting Professor at numerous universities worldwide. She is member of ENETS /UKINETS and participated in the development of German ENETS Database. Professor Frilling has received various prestigious awards including the Hermann-K'mmel-Award of the Association of Surgeons of North-Western Germany, the Hans Creutzig-Award of the German Society of Nuclear Medicine, The Endocrine Society and Pfizer, Inc. International Award for Excellence in Published Clinical Research, the Erasmus-Heusener- Award of the Surgical Society of Lower Rhine-Westphalia and the Award of the International Hepato-Pancreato-Biliary Association.

Her research work on inhibition of oncogenic RET signalling by adenovector-mediated expression of a dominant negative RET mutant in medullary thyroid carcinoma and on identification of molecular genetic risk factors in hepatocellular carcinoma, respectively has been awarded by significant funds of the German Research Society. The German Cancer Foundation provided grants for her work on presymptomatic genetic screening in patients with familial medullary thyroid carcinoma. Her basic research signature areas in the field of endocrine surgery in the past were differentiated thyroid tumors. She was a founding member of the international consortium that identified specific mutations of the RET protooncogene as the underlying genetic cause of the hereditary variant of medullary thyroid carcinoma and set up studies on genotype-phenotype correlation in multiple endocrine neoplasia type 2 and familial medullary carcinoma. Her further research was aimed to determine the molecular aetiology of follicular thyroid tumors and to improve the accuracy of diagnosis, clinical management and therapy of these distinct neoplasias. Gene-expression profiling and metabonomic profiling in neuroendocrine gastroenteropancreatic tumors accounts for areas of her present research work.

Professor Frilling conducted comprehensive clinical research on multimodal treatment of neuroendocrine liver metastases. She showed that they appear in three different growth types which are predictive of outcome. In addition, she works intensively towards clinical implementation of novel specific imaging techniques and treatment options such as 68 Ga-DOTATOC PET/CT and Lu-PRRT. Most recently her interdisciplinary group at the Imperial College London successfully accomplished the ENETS certification programm for Centers of Excellence for Management of Neuroendocrine Tumors with an emphasis on early diagnosis, multimodal treatment and translational research.

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